The Neuropharmacology of Addictions and Degenerative Disorders (NEUROFAN) group at San Pablo CEU University is a consolidated research group led by Gonzalo Herradón.

The NEUROFAN group carries out all the phases of identifying new biomarkers and therapeutic targets in diseases of the central nervous system, such as addictive disorders or neurodegenerative diseases, as well as the preclinical validation of new compounds with therapeutic potential. Our goal is to understand the molecular mechanisms involved in drug addiction and neurodegenerative diseases or diseases that occur with neurodegeneration such as alcoholism. A common mechanism in this type of pathology is neuroinflammation, which, when it becomes chronic, aggravates neurodegenerative processes. Therefore, we have a great interest in studying the mechanisms that trigger neuroinflammation and perpetuate it. This has led us to discover new targets in neuroinflammation and to study their pharmacological modulation as a new therapeutic strategy in multiple diseases that occur with neuroinflammatory processes.



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RIAPAd’s 2024 meeting

It is our pleasure to invite you to RIAPAd’s external scientific committee meeting scheduled to take place in Barcelona on…

IV Jornada Adicción y Mujeres: olvidadas e invisibles

El próximo 30 de noviembre a las 16h se celebrará en el salón de actos de la Facultad de Psicología…

Un biomarcador identifica a los pacientes alcohólicos en periodo de abstinencia que presentan deterioro cognitivo

La investigación encabezada por la Universidad Complutense de Madrid (UCM) y el Instituto de Investigación i+12 del Hospital 12 de…


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Genetic deletion or tyrosine phosphatase inhibition of PTPRZ1 activates c-Met to up-regulate angiogenesis and lung adenocarcinoma growth.

Pinelopi Kastana, Despoina Ntenekou, Eleni Mourkogianni, Michaela-Karina Enake, Athanasios Xanthopoulos, Effrosyni Choleva, Antonia Marazioti, Sophia Nikou, Racheal G Akwii, Eleni Papadaki, Esther Gramage, Gonzalo Herradón, Georgios T Stathopoulos, Constantinos M Mikelis, Evangelia Papadimitriou

Int J Cancer. 2023 Sep 1;153(5):1051-1066. doi: 10.1002/ijc.34564. Epub 2023 Jun 1.PMID: 37260355

Implication of the PTN/RPTPβ/ζ Signaling Pathway in Acute Ethanol Neuroinflammation in Both Sexes: A Comparative Study with LPS.

Rodríguez-Zapata M; Galán-Llario M; Cañeque-Rufo H; Sevillano J; Sánchez-Alonso MG; Zapico JM; Ferrer-Alcón M; Uribarri M; Pascual-Teresa Bd; Ramos-Álvarez MdP; Herradón G, Pérez-García C; Gramage E.

Biomedicines. 2023 Apr 28;11(5):1318. doi: 10.3390/biomedicines11051318. PMID: 37238989; PMCID: PMC10215719.

Pleiotrophin deficiency protects against high-fat diet-induced neuroinflammation: Implications for brain mitochondrial dysfunction and aberrant protein aggregation. 

Cañeque-Rufo H, Sánchez-Alonso MG, Zuccaro A, Sevillano J, Ramos-Álvarez MDP, Herradón G.

Food Chem Toxicol. 2023 Feb;172:113578. doi: 10.1016/j.fct.2022.113578. Epub 2022 Dec 23. PMID: 36566969.