WHAT IS NEUROFAN?

The Neuropharmacology of Addictions and Degenerative Disorders (NEUROFAN) group at San Pablo CEU University is a consolidated research group led by Gonzalo Herradón.

The NEUROFAN group carries out all the phases of identifying new biomarkers and therapeutic targets in diseases of the central nervous system, such as addictive disorders or neurodegenerative diseases, as well as the preclinical validation of new compounds with therapeutic potential. Our goal is to understand the molecular mechanisms involved in drug addiction and neurodegenerative diseases or diseases that occur with neurodegeneration such as alcoholism. A common mechanism in this type of pathology is neuroinflammation, which, when it becomes chronic, aggravates neurodegenerative processes. Therefore, we have a great interest in studying the mechanisms that trigger neuroinflammation and perpetuate it. This has led us to discover new targets in neuroinflammation and to study their pharmacological modulation as a new therapeutic strategy in multiple diseases that occur with neuroinflammatory processes.

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Adolescent intermittent ethanol exposure decreases perineuronal nets in the hippocampus in a sex dependent manner: Modulation through pharmacological inhibition of RPTPβ/ζ.

Galán-Llario M, Gramage E, García-Guerra A, Torregrosa AB, Gasparyan A, Navarro D, Navarrete F, García-Gutiérrez MS, Manzanares J, Herradón G.

Neuropharmacology. 2024 Apr 1;247:109850. doi: 10.1016/j.neuropharm.2024.109850. Epub 2024 Jan

Constitutive Pleiotrophin Deletion Results in a Phenotype with an Altered Pancreatic Morphology and Function in Old Mice.

Ballesteros-Pla C, Sevillano J, Sánchez-Alonso MG, Limones M, Pita J, Zapatería B, Sanz-Cuadrado MI, Pizarro-Delgado J, Izquierdo-Lahuerta A, Medina-Gómez G, Herradón G, Ramos-Álvarez MDP.

Int J Mol Sci. 2024 Oct 11;25(20):10960. doi: 10.3390/ijms252010960.PMID: 39456743 

Pleiotrophin modulates acute and long-term LPS-induced neuroinflammatory responses and hippocampal neurogenesis.

Rodríguez-Zapata M, López-Rodríguez R, Ramos-Álvarez MDP, Herradón G, Pérez-García C, Gramage E.

Toxicology. 2024 Dec;509:153947. doi: 10.1016/j.tox.2024.153947. Epub 2024 Sep 8.PMID: 39255863